Management of the Gastrointestinal System Bleeding Caused by Direct-Acting Oral Anticoagulants

Direct-acting oral anticoagulants include dabigatran, which is a thrombin inhibitor, and rivaroxaban, apixaban, edoxaban, are anti-Xa agents. These administered in the secondary prophylaxis treatment of venous thromboembolism (VTE) pulmonary embolism (PE), VTE that may develop after major elective orthopedic surgery, reducing stroke systemic occur non-valvular atrial fibrillation, whereas its use acute coronary syndrome still controversial. Although it specified direct-acting as effective heparin therapy reduce risk bleeding due to all causes, many important studies have also reported they increase gastrointestinal system (GIS) bleeding.